In this study, a leak detection and repair program was conducted on five pharmaceutical factories in China to analyze the volatile organic compounds (VOCs) emission characteristics of leaking equipment. The results indicated that the monitored components were mainly flanges, accounting for 70.23% of the total, and open-ended lines were the components most prone to leaks. The overall percentage of VOCs emissions reduction after the repair was 20.50%, and flanges were the most repairable components, with an average emission reduction of 47.5 kg/a for each flange. In addition, atmospheric predictions were conducted for the VOCs emissions before and after the repair of the components at the research factories. The atmospheric predictions showed that emissions from equipment and facilities have a noticeable impact on VOCs concentration at boundary and the emissions are positively correlated with the pollution source strength. The hazard quotient of the investigated factories was lower than the acceptable risk level set by the US Environmental Protection Agency (EPA). The quantitative assessment of the lifetime cancer risk showed that the risk levels of factories A, C, and D exceeded the EPA's acceptable risk level, and the on-site workers were exposed to inhalation cancer risk.
Keywords: Volatile organic compounds (VOCs); atmospheric prediction; health risk; leak detection and repair (LDAR); pharmaceutical industry.