Xanthomicrol: Effective therapy for cancer treatment

Neda Poormolaie; Mohammad Mohammadi; Amirabbas Mir; Mehrdad Asadi; Alireza Nouhi Kararoudi; Vahid Vahedian; Mohsen Rashidi; Nazila Fathi Maroufi

doi:10.1016/j.toxrep.2023.02.008

Xanthomicrol: Effective therapy for cancer treatment

Toxicol Rep. 2023 Feb 21:10:436-440. doi: 10.1016/j.toxrep.2023.02.008. eCollection 2023.

Authors

Neda Poormolaie¹, Mohammad Mohammadi², Amirabbas Mir³, Mehrdad Asadi⁴, Alireza Nouhi Kararoudi⁵, Vahid Vahedian^{6

7}, Mohsen Rashidi^{8

9}, Nazila Fathi Maroufi⁶

Affiliations

¹ Department of Biochemistry, Faculty of Biology Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.
² Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
³ Institute of Nano Science and Nano Technology, University of Kashan, P.O. Box 87317-51167, Kashan, Iran.
⁴ Department of Medical Laboratory Sciences and Microbiology, Faculty of Medical Sciences, Tabriz Medical sciences, Islamic Azad University,Tabriz, Iran.
⁵ Department of Molecular Cell Biology, Rasht Branch of Islamic Azad University, Rasht, Iran.
⁶ Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁷ Department of Medical Clinic Division Hematology/Oncology and Cellular Therapy, Sao Paulo State Cancer Hospital (ICESP), Faculty of Sao Paulo (FMUSP), Sao Paulo, Brazil.
⁸ The Department of Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
⁹ The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Abstract

Cancer treatment is one of the main challenges of global health. For decades, researchers have been trying to find anti-cancer compounds with minimal side effects. In recent years, flavonoids, as a group of polyphenolic compounds, have attracted the attention of researchers due to their beneficial effects on health. Xanthomicrol is one of the flavonoids that has the ability to inhibit growth, proliferation, survival and cell invasion and ultimately tumor progression. Xanthomicrol, as active anti-cancer compounds, can be effective in the prevention and treatment of cancer. Therefore, the use of flavonoids can be suggested as a treatment along with other medicinal agents. It is obvious that additional investigations in cellular levels and animal models are still needed. In this review article, the effects of xanthomicrol on various cancers have been reviewed.

Keywords: Apoptosis; Cancer; Treatment; Xanthomicrol.

Publication types

Review