Long non-coding RNAs and gastric cancer: An update of potential biomarkers and therapeutic applications

Sayedeh Azimeh Hosseini; Mohammad Hossein Haddadi; Hadis Fathizadeh; Foroogh Nemati; Hooman Mahmoudi Aznaveh; Farima Taraj; AmirArsalan Aghabozorgizadeh; Golmaryam Gandomkar; Elaheh Bazazzadeh

doi:10.1016/j.biopha.2023.114407

Long non-coding RNAs and gastric cancer: An update of potential biomarkers and therapeutic applications

Biomed Pharmacother. 2023 Jul:163:114407. doi: 10.1016/j.biopha.2023.114407. Epub 2023 Apr 24.

Authors

Sayedeh Azimeh Hosseini¹, Mohammad Hossein Haddadi², Hadis Fathizadeh³, Foroogh Nemati⁴, Hooman Mahmoudi Aznaveh⁵, Farima Taraj⁶, AmirArsalan Aghabozorgizadeh⁷, Golmaryam Gandomkar⁶, Elaheh Bazazzadeh⁵

Affiliations

¹ Department of Medical Biotechnology, School of Advanced Technology, Shahrekord University of Medical Sciences, Shahrekord, Iran; Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran; USERN office, Shahrekord University of Medical Sciences, Shahrekord, Iran.
² Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran. Electronic address: haddadi841@gmail.com.
³ Student Research Committee, Sirjan School of Medical Sciences, Sirjan, Iran; Department of Laboratory sciences, Sirjan School of Medical Sciences, Sirjan, Iran.
⁴ Department of Microbiology, Kashan University of Medical Sciences, Kashan, Iran.
⁵ Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, P.O. Box: 14115-154, Tehran, Iran.
⁶ Department of Animal Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.
⁷ Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Technology, University of Isfahan, Isfahan, Iran.

PMID: 37100014
DOI: 10.1016/j.biopha.2023.114407

Abstract

The frequent metastasis of gastric cancer (GC) complicates the cure and therefore the development of effective diagnostic and therapeutic approaches is urgently necessary. In recent years, lncRNA has emerged as a drug target in the treatment of GC, particularly in the areas of cancer immunity, cancer metabolism, and cancer metastasis. This has led to the demonstration of the importance of these RNAs as prognostic, diagnostic and therapeutic agents. In this review, we provide an overview of the biological activities of lncRNAs in GC development and update the latest pathological activities, prognostic and diagnostic strategies, and therapeutic options for GC-related lncRNAs.

Keywords: Cancer treatment; Clinical relevance; Diagnostic; Gastric cancer; Long non-coding RNA; Molecular mechanisms.

Publication types

Review

MeSH terms

Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism
Humans
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism
Stomach Neoplasms* / diagnosis
Stomach Neoplasms* / drug therapy
Stomach Neoplasms* / genetics

Substances

RNA, Long Noncoding
Biomarkers, Tumor