RNA modifications in cancer

Qiling Tang; Lvyuan Li; Yumin Wang; Pan Wu; Xiangchan Hou; Jiawei Ouyang; Chunmei Fan; Zheng Li; Fuyan Wang; Can Guo; Ming Zhou; Qianjin Liao; Hui Wang; Bo Xiang; Weihong Jiang; Guiyuan Li; Zhaoyang Zeng; Wei Xiong

doi:10.1038/s41416-023-02275-1

RNA modifications in cancer

Br J Cancer. 2023 Aug;129(2):204-221. doi: 10.1038/s41416-023-02275-1. Epub 2023 Apr 24.

Authors

Qiling Tang^{1

2}, Lvyuan Li^{1

2}, Yumin Wang^{2

3}, Pan Wu^{1

2}, Xiangchan Hou^{1

2}, Jiawei Ouyang^{1

2}, Chunmei Fan^{1

2}, Zheng Li², Fuyan Wang², Can Guo², Ming Zhou², Qianjin Liao¹, Hui Wang¹, Bo Xiang^{1

2}, Weihong Jiang³, Guiyuan Li^{1

2}, Zhaoyang Zeng^{1

2}, Wei Xiong^{4

5}

Affiliations

¹ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 410078, Changsha, Hunan, China.
² Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China.
³ Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, 410078, Changsha, Hunan, China.
⁴ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 410078, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁵ Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China. xiongwei@csu.edu.cn.

Abstract

Currently, more than 170 modifications have been identified on RNA. Among these RNA modifications, various methylations account for two-thirds of total cases and exist on almost all RNAs. Roles of RNA modifications in cancer are garnering increasing interest. The research on m⁶A RNA methylation in cancer is in full swing at present. However, there are still many other popular RNA modifications involved in the regulation of gene expression post-transcriptionally besides m⁶A RNA methylation. In this review, we focus on several important RNA modifications including m¹A, m⁵C, m⁷G, 2'-O-Me, Ψ and A-to-I editing in cancer, which will provide a new perspective on tumourigenesis by peeking into the complex regulatory network of epigenetic RNA modifications, transcript processing, and protein translation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Methylation
Neoplasms* / genetics
RNA / genetics
RNA / metabolism
RNA Processing, Post-Transcriptional*
RNA, Messenger / metabolism

Substances

RNA, Messenger
RNA