Biomaterial-assisted tumor therapy: A brief review of hydroxyapatite nanoparticles and its composites used in bone tumors therapy

Quan Zhang; Lei Qiang; Yihao Liu; Minjie Fan; Xinxin Si; Pengfei Zheng

doi:10.3389/fbioe.2023.1167474

Biomaterial-assisted tumor therapy: A brief review of hydroxyapatite nanoparticles and its composites used in bone tumors therapy

Front Bioeng Biotechnol. 2023 Apr 7:11:1167474. doi: 10.3389/fbioe.2023.1167474. eCollection 2023.

Authors

Quan Zhang^{1

2}, Lei Qiang^{1

3}, Yihao Liu^{1

4}, Minjie Fan¹, Xinxin Si², Pengfei Zheng¹

Affiliations

¹ Department of Orthopaedic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China.
² Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang, China.
³ School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China.
⁴ Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

Malignant bone tumors can inflict significant damage to affected bones, leaving patients to contend with issues like residual tumor cells, bone defects, and bacterial infections post-surgery. However, hydroxyapatite nanoparticles (nHAp), the principal inorganic constituent of natural bone, possess numerous advantages such as high biocompatibility, bone conduction ability, and a large surface area. Moreover, nHAp's nanoscale particle size enables it to impede the growth of various tumor cells via diverse pathways. This article presents a comprehensive review of relevant literature spanning the past 2 decades concerning nHAp and bone tumors. The primary goal is to explore the mechanisms responsible for nHAp's ability to hinder tumor initiation and progression, as well as to investigate the potential of integrating other drugs and components for bone tumor diagnosis and treatment. Lastly, the article discusses future prospects for the development of hydroxyapatite materials as a promising modality for tumor therapy.

Keywords: MFH; PTT; bone tumor therapy; drug delivery; hydroxyapatite nanoparticles; tumor cell apoptosis.

Publication types

Review

Grants and funding

This work was sponsered by Jiangsu Provincial Key Research and Development Program (CN) (BE2019608), and Jiangsu Health Commission Medical Research Program (2020158), and Nanjing Science and Technique Development Plan Medical and Health International Joint Research and Development Program, and Nanjing Medical Science and Technology Development Key Program (ZKX18041), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).