Advancing the reporting of mechanisms in implementation science: A guideline for reporting mediation analyses (AGReMA)

Aidan G Cashin; James H McAuley; Hopin Lee

doi:10.1177/26334895221105568

Advancing the reporting of mechanisms in implementation science: A guideline for reporting mediation analyses (AGReMA)

Implement Res Pract. 2022 Jun 6:3:26334895221105568. doi: 10.1177/26334895221105568. eCollection 2022 Jan-Dec.

Authors

Aidan G Cashin^{1

2}, James H McAuley^{1

2}, Hopin Lee^{3

4}

Affiliations

¹ Centre for Pain IMPACT, Neuroscience Research Australia, Sydney, Australia.
² School of Health Sciences, Faculty of Medicine & Health, University of New South Wales, Sydney, Australia.
³ Centre for Statistics in Medicine, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.
⁴ School of Medicine and Public Health, University of Newcastle, Newcastle, Australia.

Abstract

Well-conducted mediation analyses have the potential to move implementation science forward by better understanding how or why implementation strategies cause their effects on outcomes. The AGReMA statement provides authors with recommendations for reporting primary and secondary mediation analyses of randomized trials and observational studies. Improved reporting of studies that use mediation analyses could help produce publications that are complete, accurate, transparent, and reproducible.

Keywords: implementation science; mechanism; mediation analysis; reporting guideline.