Role of CD147 in the development and diagnosis of hepatocellular carcinoma

Defa Huang; Dingyu Rao; Qing Jin; Mi Lai; Jiali Zhang; Zhonghong Lai; Haibin Shen; Tianyu Zhong

doi:10.3389/fimmu.2023.1149931

Role of CD147 in the development and diagnosis of hepatocellular carcinoma

Front Immunol. 2023 Apr 6:14:1149931. doi: 10.3389/fimmu.2023.1149931. eCollection 2023.

Authors

Defa Huang¹, Dingyu Rao², Qing Jin¹, Mi Lai¹, Jiali Zhang³, Zhonghong Lai⁴, Haibin Shen¹, Tianyu Zhong^{1

5}

Affiliations

¹ Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
² Department of Cardiothoracic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
³ The First School of Clinical Medicine, Gannan Medical University, Ganzhou, China.
⁴ Department of traumatology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
⁵ Precision Medicine Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

Abstract

Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and the third leading cause of cancer-related deaths worldwide. HCC is characterized by insidious onset, and most patients are diagnosed at an advanced stage with a poor prognosis. Identification of biomarkers for HCC onset and progression is imperative to development of effective diagnostic and therapeutic strategies. CD147 is a glycoprotein that is involved in tumor cell invasion, metastasis and angiogenesis through multiple mechanisms. In this review, we describe the molecular structure of CD147 and its role in regulating HCC invasion, metastasis and angiogenesis. We highlight its potential as a diagnostic and therapeutic target for HCC.

Keywords: CD147; angiogenesis; diagnosis; hepatocellular carcinoma; metastasis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Hepatocellular* / diagnosis
Carcinoma, Hepatocellular* / pathology
Cell Line, Tumor
Humans
Liver Neoplasms* / diagnosis
Liver Neoplasms* / pathology

Grants and funding

This work was supported by funds from the National Natural Science Foundation of China (Grant No. 82260422), and Key R&D Planning Project of Jiangxi Science and Technology Commission, China (No. 20203BBGL73126).