Molecular diversity of 23-YSTR markers in Iraqi populations

Mohammed Mahdi Al-Zubaidi; Majeed Arsheed Sabbah; Hanan Khaleel Mahmood

doi:10.1016/j.gene.2023.147440

Molecular diversity of 23-YSTR markers in Iraqi populations

Gene. 2023 Jul 1:872:147440. doi: 10.1016/j.gene.2023.147440. Epub 2023 Apr 23.

Authors

Mohammed Mahdi Al-Zubaidi¹, Majeed Arsheed Sabbah², Hanan Khaleel Mahmood³

Affiliations

¹ Department Molecular genetics and DNA fingerprinting, Forensic DNA Research and Training Center, Al-Nahrain University, Baghdad, Iraq. Electronic address: molecular_fdna@nahrainuniv.edu.iq.
² Department Molecular genetics and DNA fingerprinting, Forensic DNA Research and Training Center, Al-Nahrain University, Baghdad, Iraq. Electronic address: molecular_fdna@ced.nahrainuniv.edu.iq.
³ Ministy of Health/medical Legal Dirctorate /paternity and Kinship Section, Iraq. Electronic address: Dir_ham2001@yahoo.com.

PMID: 37088231
DOI: 10.1016/j.gene.2023.147440

Abstract

Iraq is home to the ancient civilization, of Mesopotamia. The population genetics of Iraqis is important due to their ethnic diversity. This study aimed to analyze is to analyze the distribution of Y chromosome haplotypes in a sample of 680 native Iraqi males from regions of Iraq and compare it to previously published Y chromosome haplotype data from some neighboring Arab populations.In this study, A total of 680 unrelated samples (not belonging to the same nuclear family) of healthy males were sampled for the Y-STR analysis from the Iraqi populations in Baghdad. blood samples were collected at the ministry of health/medical legal Directorate/paternity and Baghdad from 2018 to 2020. Allele frequency and gene diversity were calculated. The Iraqi population data were compared with the neighboring populations using pairwise genetic distances using the Y Chromosome Haplotype Reference Database Website (YHRD) software.The discrimination capacity 23 STR loci provide was (0.92). The number of haplotypes observed in 680 samples, was 616 haplotypes (568 unique and 48 shared haplotypes). Haplogroup prediction suggests that haplogroup J1 is the most common in the Iraqi population, followed by J2. According to AMOVA and MD, showed high similarities with neighboring countries. We can conclude that there is no genetic structure among the populations and their data could be added to reference the Iraqi database.

Keywords: Forensic genetics; Iraq; Y chromosome STRs.

MeSH terms

Arabs
Chromosomes, Human, Y* / genetics
Gene Frequency
Genetics, Population*
Haplotypes
Humans
Iraq
Male
Microsatellite Repeats / genetics