Mechanical characterization of a novel biomimetic artificial disc for the cervical spine

Celien A M Jacobs; S Amir Kamali; Abdelrahman M Abdelgawad; Björn P Meij; Samaneh Ghazanfari; Marianna A Tryfonidou; Stefan Jockenhoevel; Keita Ito

doi:10.1016/j.jmbbm.2023.105808

Mechanical characterization of a novel biomimetic artificial disc for the cervical spine

J Mech Behav Biomed Mater. 2023 Jun:142:105808. doi: 10.1016/j.jmbbm.2023.105808. Epub 2023 Apr 7.

Authors

Celien A M Jacobs¹, S Amir Kamali², Abdelrahman M Abdelgawad³, Björn P Meij⁴, Samaneh Ghazanfari⁵, Marianna A Tryfonidou⁶, Stefan Jockenhoevel⁷, Keita Ito⁸

Affiliations

¹ Orthopedic Biomechanics, Dept. of Biomedical Engineering, Eindhoven University of Technology, De Rondom 70, 5612, AP, Eindhoven, the Netherlands. Electronic address: c.a.m.jacobs@tue.nl.
² Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584, CM, Utrecht, the Netherlands. Electronic address: s.a.kamali@uu.nl.
³ Aachen-Maastricht Institute for Biobased Materials, Faculty of Science and Engineering, Maastricht University, Brightlands Chemelot Campus, Urmonderbaan, 226167, RD, Geleen, the Netherlands; Department of Biohybrid and Medical Textiles (BioTex), AME - Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Forckenbeckstraβe 55, 52074, Aachen, Germany. Electronic address: Aabdelgawad2@gmail.com.
⁴ Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584, CM, Utrecht, the Netherlands. Electronic address: B.P.Meij@uu.nl.
⁵ Aachen-Maastricht Institute for Biobased Materials, Faculty of Science and Engineering, Maastricht University, Brightlands Chemelot Campus, Urmonderbaan, 226167, RD, Geleen, the Netherlands; Department of Biohybrid and Medical Textiles (BioTex), AME - Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Forckenbeckstraβe 55, 52074, Aachen, Germany. Electronic address: Samaneh.ghazanfari@maastrichtuniversity.nl.
⁶ Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584, CM, Utrecht, the Netherlands. Electronic address: Tryfonidou@uu.nl.
⁷ Aachen-Maastricht Institute for Biobased Materials, Faculty of Science and Engineering, Maastricht University, Brightlands Chemelot Campus, Urmonderbaan, 226167, RD, Geleen, the Netherlands; Department of Biohybrid and Medical Textiles (BioTex), AME - Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Forckenbeckstraβe 55, 52074, Aachen, Germany. Electronic address: stefan.jockenhovel@maastrichtuniversity.nl.
⁸ Orthopedic Biomechanics, Dept. of Biomedical Engineering, Eindhoven University of Technology, De Rondom 70, 5612, AP, Eindhoven, the Netherlands. Electronic address: k.ito@tue.nl.

PMID: 37087956
DOI: 10.1016/j.jmbbm.2023.105808

Abstract

A novel biomimetic artificial intervertebral disc (bioAID) replacement implant has been developed containing a swelling hydrogel representing the nucleus pulposus, a tensile strong fiber jacket as annulus fibrosus and titanium endplates with pins to primarily secure the device between the vertebral bodies. In this study, the design safety of this novel implant was evaluated based on several biomechanical parameters, namely compressive strength, shear-compressive strength, risk of subsidence and device expulsion as well as identifying the diurnal creep-recovery characteristics of the device. The bioAID remained intact up to 1 kN under static axial compression and only 0.4 mm of translation was observed under a compressive shear load of 20 N. No subsidence was observed after 0.5 million cycles of sinusoidal compressive loading between 50 and 225 N. After applying 400 N in antero-posterior direction under 100 N axial compressive preload, approximately 2 mm displacement was found, being within the range of displacements reported for other commercially available cervical disc replacement devices. The diurnal creep recovery behavior of the bioAID closely resembled what has been reported for natural intervertebral discs in literature. Overall, these results indicate that the current design can withstand (shear-compression loads and is able to remain fixed in a mechanical design resembling the vertebral bodies. Moreover, it is one of the first implants that can closely mimic the poroelastic and viscoelastic behavior of natural disc under a diurnal loading pattern.

Keywords: Biomechanical; Biomimetic; Cervical disc replacement.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Annulus Fibrosus*
Biomechanical Phenomena
Biomimetics
Cervical Vertebrae / surgery
Compressive Strength
Intervertebral Disc* / surgery
Lumbar Vertebrae
Stress, Mechanical
Weight-Bearing