Alleviative effects of natural plant polysaccharides against DSS-induced ulcerative colitis via inhibiting inflammation and modulating gut microbiota

Hanyu Lu; Mingyue Shen; Yi Chen; Qiang Yu; Ting Chen; Jianhua Xie

doi:10.1016/j.foodres.2023.112630

Alleviative effects of natural plant polysaccharides against DSS-induced ulcerative colitis via inhibiting inflammation and modulating gut microbiota

Food Res Int. 2023 May:167:112630. doi: 10.1016/j.foodres.2023.112630. Epub 2023 Feb 24.

Authors

Hanyu Lu¹, Mingyue Shen¹, Yi Chen¹, Qiang Yu¹, Ting Chen¹, Jianhua Xie²

Affiliations

¹ State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
² State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China. Electronic address: jhxie@ncu.edu.cn.

PMID: 37087227
DOI: 10.1016/j.foodres.2023.112630

Abstract

Ulcerative colitis (UC) treatment usually involves either drug therapy or surgery. Natural food polysaccharides have showed great potential for preventing UC. In this study, the therapeutic effects of Cyclocarya paliurus (Batal.) Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored. The results suggested that CP and CYP could improve colitis symptoms in DSS-induced mice, enhance the production of IL-10, inhibit cytokines (IL-1β, TNF-α) and reduce MPO activity. Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver. Finally, they modulated the composition and metabolism of gut microbiota. Notably, Alistipes and Bacteroides were the specific genera in CP and CYP groups, respectively. These findings indicated that polysaccharides might alleviate the development of colitis and inform other relevant studies.

Keywords: Gut microbiota; Intestinal barrier; Polysaccharides; Short-chain fatty acids; Ulcerative colitis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Colitis* / chemically induced
Colitis, Ulcerative* / chemically induced
Colitis, Ulcerative* / drug therapy
Dextran Sulfate / adverse effects
Disease Models, Animal
Gastrointestinal Microbiome*
Inflammation
Mice

Substances

Dextran Sulfate