Luminescent quantum dots: Synthesis, optical properties, bioimaging and toxicity

Jeladhara Sobhanan; Jose V Rival; Abdulaziz Anas; Edakkattuparambil Sidharth Shibu; Yuta Takano; Vasudevanpillai Biju

doi:10.1016/j.addr.2023.114830

Luminescent quantum dots: Synthesis, optical properties, bioimaging and toxicity

Adv Drug Deliv Rev. 2023 Jun:197:114830. doi: 10.1016/j.addr.2023.114830. Epub 2023 Apr 20.

Authors

Jeladhara Sobhanan¹, Jose V Rival², Abdulaziz Anas³, Edakkattuparambil Sidharth Shibu⁴, Yuta Takano⁵, Vasudevanpillai Biju⁶

Affiliations

¹ Graduate School of Environmental Science, Hokkaido University, N10 W5, Sapporo, Hokkaido 060-0810, Japan; Department of Chemistry, Rice University, 6100 Main St., Houston, TX 77005, USA.
² Smart Materials Lab, Department of Nanoscience and Technology, University of Calicut, Kerala, India.
³ CSIR-National Institute of Oceanography, Regional Centre Kochi, Kerala 682 018, India. Electronic address: anas@nio.org.
⁴ Smart Materials Lab, Department of Nanoscience and Technology, University of Calicut, Kerala, India. Electronic address: shibu@uoc.ac.in.
⁵ Graduate School of Environmental Science, Hokkaido University, N10 W5, Sapporo, Hokkaido 060-0810, Japan; Research Institute for Electronic Science, Hokkaido University, Sapporo 001-0020, Japan.
⁶ Graduate School of Environmental Science, Hokkaido University, N10 W5, Sapporo, Hokkaido 060-0810, Japan; Research Institute for Electronic Science, Hokkaido University, Sapporo 001-0020, Japan. Electronic address: biju@es.hokudai.ac.jp.

PMID: 37086917
DOI: 10.1016/j.addr.2023.114830

Abstract

Luminescent nanomaterials such as semiconductor nanocrystals (NCs) and quantum dots (QDs) attract much attention to optical detectors, LEDs, photovoltaics, displays, biosensing, and bioimaging. These materials include metal chalcogenide QDs and metal halide perovskite NCs. Since the introduction of cadmium chalcogenide QDs to biolabeling and bioimaging, various metal nanoparticles (NPs), atomically precise metal nanoclusters, carbon QDs, graphene QDs, silicon QDs, and other chalcogenide QDs have been infiltrating the nano-bio interface as imaging and therapeutic agents. Nanobioconjugates prepared from luminescent QDs form a new class of imaging probes for cellular and in vivo imaging with single-molecule, super-resolution, and 3D resolutions. Surface modified and bioconjugated core-only and core-shell QDs of metal chalcogenides (MX; M = Cd/Pb/Hg/Ag, and X = S/Se/Te,), binary metal chalcogenides (MInX₂; M = Cu/Ag, and X = S/Se/Te), indium compounds (InAs and InP), metal NPs (Ag, Au, and Pt), pure or mixed precision nanoclusters (Ag, Au, Pt), carbon nanomaterials (graphene QDs, graphene nanosheets, carbon NPs, and nanodiamond), silica NPs, silicon QDs, etc. have become prevalent in biosensing, bioimaging, and phototherapy. While heavy metal-based QDs are limited to in vitro bioanalysis or clinical testing due to their potential metal ion-induced toxicity, carbon (nanodiamond and graphene) and silicon QDs, gold and silica nanoparticles, and metal nanoclusters continue their in vivo voyage towards clinical imaging and therapeutic applications. This review summarizes the synthesis, chemical modifications, optical properties, and bioimaging applications of semiconductor QDs with particular references to metal chalcogenide QDs and bimetallic chalcogenide QDs. Also, this review highlights the toxicity and pharmacokinetics of QD bioconjugates.

Keywords: Bioconjugation; Cell imaging; Cell labelling; Fluorescence; In vivo imaging; Nanocrystals; Nanotoxicity; Pharmacokinetics; Photoluminescence; Phototherapy; Quantum dots.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Graphite*
Humans
Nanodiamonds*
Quantum Dots* / chemistry
Quantum Dots* / toxicity
Silicon / chemistry
Silicon Dioxide

Substances

Silicon
Nanodiamonds
Graphite
Silicon Dioxide