Targeting neddylation as a novel approach to lung cancer treatment (Review)

Zhaochun Tian; Jiafei Li; Ruijie Ma; Ting Li; Zhigang Sun; Shuhong Huang

doi:10.3892/ijo.2023.5513

Targeting neddylation as a novel approach to lung cancer treatment (Review)

Int J Oncol. 2023 May;62(5):65. doi: 10.3892/ijo.2023.5513. Epub 2023 Apr 21.

Authors

Zhaochun Tian¹, Jiafei Li², Ruijie Ma³, Ting Li², Zhigang Sun³, Shuhong Huang¹

Affiliations

¹ Science and Technology Innovation Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250117, P.R. China.
² School of Clinical and Basic Medical Sciences, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250117, P.R. China.
³ Department of Thoracic Surgery, Jinan Central Hospital, Shandong University, Jinan, Shandong 250013, P.R. China.

Abstract

As a protein that resembles ubiquitin, neural precursor cell expressed developmentally downregulated 8 (NEDD8) takes part in neddylation, which modifies substrates in a manner similar to ubiquitination and alters the activity of target proteins. Neddylation may affect the activity of multiple signaling pathways, have a regulatory role in tumor formation, progression and metastasis, and influence the prognosis of cancer treatment. The present review summarizes the regulatory roles of NEDD8 in the MDM2‑p53, NF‑κB, PI3K/AKT/mTOR, hypoxia‑inducible factor, Hippo and receptor tyrosine kinase signaling pathways, as well as in the development and progression of lung cancer.

Keywords: MLN4924; NEDD8; lung cancer; neddylation; signaling pathway; treatment.

Publication types

Review

MeSH terms

Humans
Lung Neoplasms* / drug therapy
Lung Neoplasms* / genetics
Lung Neoplasms* / pathology
NEDD8 Protein / genetics
NEDD8 Protein / metabolism
Phosphatidylinositol 3-Kinases / metabolism
Ubiquitination
Ubiquitins*

Substances

Ubiquitins
NEDD8 Protein
Phosphatidylinositol 3-Kinases

Grants and funding

This research was supported by the National Natural Science Foundation of China (grant no. 81971088) and the Innovation Project of Shandong Academy of Medical Sciences, Shandong Provincial Natural Science Foundation, China (grant no. ZR2018MC008).