Analysis of the relationship between the gut microbiota enterotypes and colorectal adenoma

Miwei Lv; Jiawei Zhang; Jiaxin Deng; Jiancong Hu; Qinghua Zhong; Mingli Su; Dezheng Lin; Tian Xu; Xuhao Bai; Juan Li; Xuefeng Guo

doi:10.3389/fmicb.2023.1097892

Analysis of the relationship between the gut microbiota enterotypes and colorectal adenoma

Front Microbiol. 2023 Apr 4:14:1097892. doi: 10.3389/fmicb.2023.1097892. eCollection 2023.

Authors

Miwei Lv^{1

2

3}, Jiawei Zhang^{1

2}, Jiaxin Deng^{1

2}, Jiancong Hu^{1

2}, Qinghua Zhong^{1

2}, Mingli Su^{1

2}, Dezheng Lin^{1

2}, Tian Xu³, Xuhao Bai³, Juan Li^{1

2}, Xuefeng Guo^{1

2}

Affiliations

¹ Department of Endoscopic Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
² Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
³ School of Medicine, Xizang Minzu University, Xianyang, China.

Abstract

Introduction: The essence of enterotypes is to stratify the entire human gut microbiota, and dysregulation of gut microbiota is closely related to the development of colorectal adenoma. Enterotypes may therefore be a useful target for the prevention of colorectal adenoma. However, the relationship between gut microbiota and colorectal adenoma has not been fully elucidated. In this study, we aimed to analyze the differences in gut microbiome composition between adenoma and control populations.

Methods: We recruited 31 patients with colorectal adenoma and 71 non-adenoma controls. Patient demographics, risk factors, fecal samples from each subject were collected and metagenomic sequencing was performed. LEfSe analysis was used to reveal differences in intestinal microbiome composition. Multiple logistic regression analysis was used to determine the association between enterotypes and colorectal adenoma.

Results: The results showed that Prevotella enterotype (enterotype 4) is only present in adenoma group. Logistic regression analysis showed that Prevotella enterotype was an independent risk factor for colorectal adenoma.

Discussion: The Prevotella enterotype may increase the occurrence of colorectal adenoma through inflammatory association and interference with glucose and lipid metabolism in human body. In conclusion, the differences we observed between different enterotypes add a new potential factor to the development of colorectal adenoma.

Keywords: Prevotella; adenoma; colorectal polyps; enterotype; gut microbiota.