Biogenic green metal nano systems as efficient anti-cancer agents

Vishal Chaudhary; Sonu; Ruchita Chowdhury; Prachi Thukral; Diksha Pathania; Shivani Saklani; Lucky; Sarvesh Rustagi; Akash Gautam; Yogendra Kumar Mishra; Pardeep Singh; Ajeet Kaushik

doi:10.1016/j.envres.2023.115933

Biogenic green metal nano systems as efficient anti-cancer agents

Environ Res. 2023 Jul 15:229:115933. doi: 10.1016/j.envres.2023.115933. Epub 2023 Apr 18.

Authors

Affiliations

¹ Research Cell & Physics Department, Bhagini Nivedita College, University of Delhi, Delhi, India; SUMAN Laboratory (SUstainable Materials and Advanced Nanotechnology Lab), New Delhi, 110072, India. Electronic address: chaudhary00vishal@gmail.com.
² School of Advanced Chemical Sciences, Shoolini University, Solan, 173229, India.
³ SUMAN Laboratory (SUstainable Materials and Advanced Nanotechnology Lab), New Delhi, 110072, India; Department of Chemistry, Netaji Subhas University of Technology, New Delhi, 110078, India.
⁴ SUMAN Laboratory (SUstainable Materials and Advanced Nanotechnology Lab), New Delhi, 110072, India; Department of Applied Chemistry, Delhi Technological University, New Delhi, 110042, India.
⁵ Animal Nutrition Division, ICAR-National Dairy Research Institute, Karnal, 132001, India.
⁶ School of Biological and Environmental Sciences, Shoolini University, Solan, 173229, India.
⁷ Dr B R Ambedkar Center for Biomedical Research, University of Delhi, Delhi, 110007, India.
⁸ School of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttrakhand, India.
⁹ Centre for Neural and Cognitive Sciences, University of Hyderabad, Hyderabad, 500046, India. Electronic address: akash@uohyd.ac.in.
¹⁰ Mads Clausen Institute, NanoSYD, University of Southern Denmark, Alison 2, 6400, Sønderborg, Denmark.
¹¹ NanoBioTech Laboratory, Department of Environmental Engineering, Florida Polytechnic University, Lakeland, FL, 33805, USA; School of Engineering, University of Petroleum and Energy Studies, Dehradun 248007, India. Electronic address: akaushik@floridapoly.edu.

PMID: 37080272
DOI: 10.1016/j.envres.2023.115933

Abstract

Metal/metal oxide nano systems (M-NSs) of tunable and manipulative properties are emerging suitable for cancer management via immunity development, early-stage diagnosis, nanotherapeutics, and targeted drug delivery systems. However, noticeable toxicity, off-targeted actions, lacking biocompatibility, and being expensive limit their acceptability. Moreover, involving high energy (top-down routes) and hazardous chemicals (bottom-up chemical routes) is altering human cycle. To manage such challenges, biomass (plants, microbes, animals) and green chemistry-based M-NSs due to scalability, affordability, are cellular, tissue, and organ acceptability are emerging as desired biogenic M-NSs for cancer management with enhanced features. The state-of-art and perspective of green metal/metal oxide nano systems (GM-NSs) as an efficient anti-cancer agent including, imaging, immunity building elements, site-specific drug delivery, and therapeutics developments are highlighted in this review critically. It is expected that this report will serve as guideline for design and develop high-performance GM-NSs for establishing them as next-generation anti-cancer agent capable to manage cancer in personalized manner.

Keywords: Anti-cancer agent; Biogenic nanoparticles; Cancer management; Drug delivery system; Green chemistry; Metal-oxides.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents* / chemistry
Antineoplastic Agents* / therapeutic use
Drug Delivery Systems
Humans
Metal Nanoparticles* / chemistry
Metal Nanoparticles* / therapeutic use
Metal Nanoparticles* / toxicity
Metals
Neoplasms* / drug therapy
Oxides

Substances

Antineoplastic Agents
Metals
Oxides