A zwitterionic solution for smart ionic liquids to evade cytotoxicity

Hsin-Heng Huang; Jianbo Jia; Luyao Ren; Shenqing Wang; Tongtao Yue; Bing Yan; Yen-Ho Chu

doi:10.1016/j.jhazmat.2023.131430

A zwitterionic solution for smart ionic liquids to evade cytotoxicity

J Hazard Mater. 2023 Jul 5:453:131430. doi: 10.1016/j.jhazmat.2023.131430. Epub 2023 Apr 15.

Authors

Hsin-Heng Huang¹, Jianbo Jia², Luyao Ren³, Shenqing Wang², Tongtao Yue⁴, Bing Yan⁵, Yen-Ho Chu⁶

Affiliations

¹ Department of Chemistry and Biochemistry and Advanced Institute of Manufacturing with High-tech Innovations, National Chung Cheng University, 621301, Taiwan, ROC.
² Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou 510006, PR China.
³ Institute of Coastal Environmental Pollution Control, Key Laboratory of Marine Environment and Ecology, Ministry of Education, Ocean University of China, Qingdao 266100, PR China.
⁴ Institute of Coastal Environmental Pollution Control, Key Laboratory of Marine Environment and Ecology, Ministry of Education, Ocean University of China, Qingdao 266100, PR China. Electronic address: yuetongtao@ouc.edu.cn.
⁵ Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou 510006, PR China. Electronic address: drbingyan@gzhu.edu.cn.
⁶ Department of Chemistry and Biochemistry and Advanced Institute of Manufacturing with High-tech Innovations, National Chung Cheng University, 621301, Taiwan, ROC. Electronic address: cheyhc@ccu.edu.tw.

PMID: 37080032
DOI: 10.1016/j.jhazmat.2023.131430

Abstract

By linking the cation and anion motifs of ionic liquids (ILs), zwitterionic liquids (ZILs) exhibit at least 146-2740 and 112-1550 folds less cytotoxicity in human gastric and colon cells than those of the structurally related ILs. Computer simulation shows that ZIL molecules hardly penetrate the cell membranes in contrast to ILs. These findings reveal a novel mechanism for ZILs to evade cytotoxicity, establishing a structure-based design principle for the next generation of sustainable ZILs.

Keywords: Biocompatible chemicals; Dynamic simulation; Green chemistry; Human health; Zwitterionic compounds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anions
Computer Simulation
Humans
Ionic Liquids* / toxicity

Substances

Ionic Liquids
Anions