Post-ischemic inflammatory response in the brain: Targeting immune cell in ischemic stroke therapy

Xueyang Shen; Mingming Li; Kangmei Shao; Yongnan Li; Zhaoming Ge

doi:10.3389/fnmol.2023.1076016

Post-ischemic inflammatory response in the brain: Targeting immune cell in ischemic stroke therapy

Front Mol Neurosci. 2023 Apr 3:16:1076016. doi: 10.3389/fnmol.2023.1076016. eCollection 2023.

Authors

Xueyang Shen¹, Mingming Li^{1

2

3}, Kangmei Shao¹, Yongnan Li⁴, Zhaoming Ge^{1

2

3}

Affiliations

¹ Department of Neurology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China.
² Gansu Provincial Neurology Clinical Medical Research Center, The Second Hospital of Lanzhou University, Lanzhou, China.
³ Expert Workstation of Academician Wang Longde, The Second Hospital of Lanzhou University, Lanzhou, China.
⁴ Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China.

Abstract

An ischemic stroke occurs when the blood supply is obstructed to the vascular basin, causing the death of nerve cells and forming the ischemic core. Subsequently, the brain enters the stage of reconstruction and repair. The whole process includes cellular brain damage, inflammatory reaction, blood-brain barrier destruction, and nerve repair. During this process, the proportion and function of neurons, immune cells, glial cells, endothelial cells, and other cells change. Identifying potential differences in gene expression between cell types or heterogeneity between cells of the same type helps to understand the cellular changes that occur in the brain and the context of disease. The recent emergence of single-cell sequencing technology has promoted the exploration of single-cell diversity and the elucidation of the molecular mechanism of ischemic stroke, thus providing new ideas and directions for the diagnosis and clinical treatment of ischemic stroke.

Keywords: glial; immune cell; ischemic stroke; neuron; single-cell sequencing.

Publication types

Review