Myelin sheath injury and repairment after subarachnoid hemorrhage

Mao Chen; Peiwen Guo; Xufang Ru; Yujie Chen; Shilun Zuo; Hua Feng

doi:10.3389/fphar.2023.1145605

Myelin sheath injury and repairment after subarachnoid hemorrhage

Front Pharmacol. 2023 Apr 3:14:1145605. doi: 10.3389/fphar.2023.1145605. eCollection 2023.

Authors

Mao Chen¹, Peiwen Guo^{2

3

4}, Xufang Ru^{2

3

4}, Yujie Chen^{2

3

4}, Shilun Zuo^{1

2

3

4}, Hua Feng^{2

3

4}

Affiliations

¹ Department of Neurology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
² Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
³ Chongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
⁴ Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

Abstract

Subarachnoid hemorrhage (SAH) can lead to damage to the myelin sheath in white matter. Through classification and analysis of relevant research results, the discussion in this paper provides a deeper understanding of the spatiotemporal change characteristics, pathophysiological mechanisms and treatment strategies of myelin sheath injury after SAH. The research progress for this condition was also systematically reviewed and compared related to myelin sheath in other fields. Serious deficiencies were identified in the research on myelin sheath injury and treatment after SAH. It is necessary to focus on the overall situation and actively explore different treatment methods based on the spatiotemporal changes in the characteristics of the myelin sheath, as well as the initiation, intersection and common action point of the pathophysiological mechanism, to finally achieve accurate treatment. We hope that this article can help researchers in this field to further clarify the challenges and opportunities in the current research on myelin sheath injury and treatment after SAH.

Keywords: myelin sheath; oligodendrocyte; secondary brain injury; subarachnoid hemorrhage; white matter.

Publication types

Review

Grants and funding

This work was supported by the Natural Science Foundation of Chongqing (No. cstc2019jcyj-msxmX0535 to SZ), National Natural Science Foundation of China (82030036 to HF), Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau, No. 2023MSXM138 to YC) and State Key Laboratory of Trauma, Burn and Combined Injury (SKLYQ202002 to YC).