Oxidative stress: The nexus of obesity and cognitive dysfunction in diabetes

Front Endocrinol (Lausanne). 2023 Apr 3:14:1134025. doi: 10.3389/fendo.2023.1134025. eCollection 2023.

Abstract

Obesity has been associated with oxidative stress. Obese patients are at increased risk for diabetic cognitive dysfunction, indicating a pathological link between obesity, oxidative stress, and diabetic cognitive dysfunction. Obesity can induce the biological process of oxidative stress by disrupting the adipose microenvironment (adipocytes, macrophages), mediating low-grade chronic inflammation, and mitochondrial dysfunction (mitochondrial division, fusion). Furthermore, oxidative stress can be implicated in insulin resistance, inflammation in neural tissues, and lipid metabolism disorders, affecting cognitive dysfunction in diabetics.

Keywords: cognitive dysfunction in diabetes; insulin resistance; lipid metabolism disorders; neuroinflammation; obesity; oxidative stress; reactive oxygen species.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diabetes Mellitus, Type 2* / complications
  • Humans
  • Inflammation / complications
  • Insulin Resistance*
  • Obesity / metabolism
  • Oxidative Stress

Grants and funding

The study was funded by Scientific and technological innovation project of China Academy of Chinese Medical Sciences”, Chinese medicine prevention and treatment of type 2 diabetes evidence-based capacity-building projects——Huashi Jiangzhuo Decoction in the treatment of newly diagnosed type 2 diabetes damp heat syndrome of multi-center randomized controlled clinical study, the national natural science foundation of China with funding number 82074412.