Roussoelins A and B: two phenols with antioxidant capacity from ascidian-derived fungus Roussoella siamensis SYSU-MS4723

Senhua Chen; Hongjie Shen; Yanlian Deng; Heng Guo; Minghua Jiang; Zhenger Wu; Huimin Yin; Lan Liu

doi:10.1007/s42995-020-00066-8

Roussoelins A and B: two phenols with antioxidant capacity from ascidian-derived fungus Roussoella siamensis SYSU-MS4723

Mar Life Sci Technol. 2020 Oct 23;3(1):69-76. doi: 10.1007/s42995-020-00066-8. eCollection 2021 Feb.

Authors

Senhua Chen^{1

2}, Hongjie Shen¹, Yanlian Deng³, Heng Guo¹, Minghua Jiang¹, Zhenger Wu¹, Huimin Yin¹, Lan Liu^{1

2}

Affiliations

¹ School of Marine Sciences, Sun Yat-Sen University, Guangzhou, 510006 China.
² Southern Laboratory of Ocean Science and Engineering (Guangdong, Zhuhai), Zhuhai, 519000 China.
³ School of Pharmacy, Guangdong Medical University, Dongguan, 523808 China.

Abstract

Ascidian-derived microorganisms are a significant source of pharmacologically active metabolites with interesting structural properties. When discovering bioactive molecules from ascidian-derived fungi, two new phenols, roussoelins A (1) and B (2), and ten known polyketides (3-12) were isolated from the ascidian-derived fungus Roussoella siamensis SYSU-MS4723. The planar structure of compounds 1 and 2 was established by analysis of HR-ESIMS and NMR data. The conformational analysis of the new compounds was assigned according to coupling constants and selective gradient NOESY experiments, and absolute configurations were completed by the modified Mosher's method. Among the isolated compounds, 1, 2, and 9 showed moderate antioxidant capacity.

Keywords: Antioxidant capacity; Ascidian-derived fungus; Phenols; Roussoella siamensis.