An Investigation into the Effects of Chemical, Pharmaceutical, and Herbal Compounds on Neuroglobin: A Literature Review

Sahar Golpour-Hamedani; Makan Pourmasoumi; Gholamreza Askari; Mohammad Bagherniya; Thozhukat Sathyapalan; Amirhossein Sahebkar

doi:10.2174/0929867330666230413093409

An Investigation into the Effects of Chemical, Pharmaceutical, and Herbal Compounds on Neuroglobin: A Literature Review

Curr Med Chem. 2023 Apr 13. doi: 10.2174/0929867330666230413093409. Online ahead of print.

Authors

Sahar Golpour-Hamedani¹, Makan Pourmasoumi², Gholamreza Askari^{3

4}, Mohammad Bagherniya^{4

3}, Thozhukat Sathyapalan⁵, Amirhossein Sahebkar^{6

7}

Affiliations

¹ Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of medical science.
² Gastrointestinal & Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
³ Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
⁴ Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
⁵ Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK.
⁶ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
⁷ Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 37069714
DOI: 10.2174/0929867330666230413093409

Abstract

Neuroglobin (Ngb) is an oxygen-binding globin protein that is mainly expressed in the neurons of the central and peripheral nervous system. However, moderate levels of Ngb have also been detected in non-neural tissues. Ngb and Ngb modulating factors have been increasingly studied over the last decade due to their neuroprotective role in neurological disorders and hypoxia. Studies have shown that a number of chemicals, pharmaceuticals, and herbal compounds can modulate the expression of Ngb at different dose levels, indicating a protective role against neurodegenerative diseases. Iron chelators, hormones, antidiabetic drugs, anticoagulants, antidepressants, plant derivatives and short-chain fatty acids are among these compounds. Therefore, this study aimed to review the literature focused on the possible effects and mechanisms of chemical, pharmaceutical, and herbal compounds on Ngbs.

Keywords: Pharmaceutical; herbal; iron chelators; metalloid; neuroglobin; neuroglobinPharmaceutical; short chain fatty acids.