Contactin-Associated Protein-Like 2-Related Peripheral Nerve Hyperexcitability Associated With Charcot-Marie-Tooth Type 4F

Joseph M Ferrara; Michael Wiid; Sean Burke

doi:10.1177/19418744221140182

Contactin-Associated Protein-Like 2-Related Peripheral Nerve Hyperexcitability Associated With Charcot-Marie-Tooth Type 4F

Neurohospitalist. 2023 Apr;13(2):164-168. doi: 10.1177/19418744221140182. Epub 2023 Feb 15.

Authors

Joseph M Ferrara^{1

2}, Michael Wiid², Sean Burke^{2

3}

Affiliations

¹ Division of Neurology, Department of Internal Medicine, East Carolina University School of Medicine, Greenville, NC, USA.
² Department of Internal Medicine, Virginia Tech Carilion, Roanoke, VA, USA.
³ Comprehensive Neurology Services, Frederick Health, Frederick, MD, USA.

Abstract

Contactin-associated protein-like 2 autoimmunity is an uncommon disorder resulting in peripheral nerve hyperexcitability or encephalitis. In a fifth of cases, onset may be provoked by thymoma, but other associations are largely unknown. We report a patient with anti-contactin-associated protein-like 2-related peripheral nerve hyperexcitability arising in the setting of Charcot-Marie-Tooth type 4F and discuss potential mechanisms underlying the association.

Keywords: charcot-marie-tooth type 4F; contactin-associated protein-like 2; dejerine-sottas neuropathy; isaac syndrome; morvan syndrome; neuromyotonia; periaxin gene; peripheral nerve hyperexcitability.