Endovascular treatment of acute basilar artery occlusion caused by vertebral artery stump syndrome: A clinical analysis of 37 cases

Keqi Lei; Weiping Chen; Zhijuan Cheng; Fang Li; Kai Wang; Min Yin; Xingen Zhu; Hua Guo; Jianglong Tu

doi:10.1016/j.heliyon.2023.e14956

Endovascular treatment of acute basilar artery occlusion caused by vertebral artery stump syndrome: A clinical analysis of 37 cases

Heliyon. 2023 Mar 28;9(4):e14956. doi: 10.1016/j.heliyon.2023.e14956. eCollection 2023 Apr.

Authors

Keqi Lei¹, Weiping Chen¹, Zhijuan Cheng¹, Fang Li¹, Kai Wang¹, Min Yin¹, Xingen Zhu², Hua Guo², Jianglong Tu¹

Affiliations

¹ Department of Neurology Second Affiliated Hospital of Nanchang University,1 Minde Road, Donghu District, Nanchang City, Jiangxi Province, China.
² Institute of Neuroscience, Nanchang University, Nanchang, China.

Abstract

Introduction: Acute basilar artery occlusion (ABAO) caused by vertebral artery stump syndrome (VASS) has a low incidence and is always underestimated. Due to the occlusion of the origin of the vertebral artery (VA), it is often combined with basilar artery (BA) endovascular diseases or non-dominant contralateral vertebral artery, making the endovascular treatment (EVT) challenging to implement.

Objective: This article focuses on whether EVT and two interventional route options could bring clinical benefits to this group of patients: basilar artery thrombectomy through the occluded lateral vertebral artery and implementing revascularization of the occluded vertebral artery (dirty-road-path); thrombectomy through the non-occluded lateral vertebral artery (clean-road-path).

Methods: We collected six cases of acute embolic basilar artery occlusion (ABAO) due to VASS from January 2020 to December 2021 at our hospital and retrospectively analyzed 31 patients previously reported in the literature and applied statistical analysis to investigate the treatment options and clinical prognosis of these patients.

Results: The clean-road-path surgical protocol was applied in 4 of 37 patients, the dirty-road-path protocol was applied in 29 patients, and 4 patients did not recanalized the basilar artery. By statistical analysis we found that successful recanalization of the basilar artery was clinically significant in reducing the modified Rankin Scale (mRS) scores in these patients, the statistical difference in the benefit of the two surgical protocols was negative. There was a significant positive correlation between preoperative National Institute of Health Stroke Scale (NIHSS) and postoperative 90-day mRS scores.

Conclusion: Endovascular treatment can benefit patients with ABAO due to VASS, and patients with higher preoperative NIHSS scores are more vulnerable to getting a poor prognosis. Comparison between the two endovascular options did not yield statistically significant results, but the dirty-road-path option may be superior to using the clean-road-path.

Keywords: Acute basilar artery occlusion (ABAO); Endovascular treatment (EVT); Ischemic stroke; Vertebral artery stump syndrome(VASS).