Primary intestinal type mucinous adenocarcinoma of the ovary diagnosed during pregnancy - Maternal and neonatal treatment and outcomes: A case report

Eliane Azeka Hase; Henrique Norio Shinohara; João Alberto Garcia Alves Filho; José Carlos Sadalla; Alexandre Muxfeldt Ab Saber; Rossana Pulcineli Vieira Francisco

doi:10.3389/fmed.2023.1138447

Primary intestinal type mucinous adenocarcinoma of the ovary diagnosed during pregnancy - Maternal and neonatal treatment and outcomes: A case report

Front Med (Lausanne). 2023 Mar 29:10:1138447. doi: 10.3389/fmed.2023.1138447. eCollection 2023.

Authors

Eliane Azeka Hase¹, Henrique Norio Shinohara², João Alberto Garcia Alves Filho¹, José Carlos Sadalla³, Alexandre Muxfeldt Ab Saber⁴, Rossana Pulcineli Vieira Francisco¹

Affiliations

¹ Department of Obstetrics and Gynecology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo Medical School, São Paulo, Brazil.
² Graduate Program, University of São Paulo Medical School, São Paulo, Brazil.
³ Department of Gynecologic Oncology, Institute of Cancer of São Paulo, São Paulo, Brazil.
⁴ Department of Pathological Anatomy, Hospital das Clínicas, Faculty of Medicine, University of São Paulo Medical School, São Paulo, Brazil.

Abstract

The incidence of ovarian cancer during pregnancy is low. Most adnexal tumors removed during pregnancy are benign, with ovarian carcinomas found in approximately 1: 10,000-1: 50,000 pregnancies. Literature on this disease is scarce and consists mostly of retrospective studies and case reports. We report the case of a pregnant patient who presented with a primary intestinal-type mucinous adenocarcinoma of the ovary and underwent unilateral salpingo-oophorectomy, with no additional surgical or chemotherapy treatment after the histological diagnosis, despite an infiltrative stromal invasion pattern. To the best of our knowledge, no such case has been previously reported. Conservative treatment in this case of early ovarian carcinoma is possible during pregnancy and should be performed in the Department of Gynecological Oncology and Obstetrics of a tertiary referral hospital. Given the possibility of disease recurrence, such patients require strict clinical oncological surveillance, specialized prenatal care, and assistance from a multidisciplinary team to improve the maternal and perinatal outcomes.

Keywords: cancer; management; mucinous carcinoma; ovary; pregnancy.

Publication types

Case Reports