Controversial role of ILC3s in intestinal diseases: A novelty perspective on immunotherapy

Yunshu Zhang; Xuefei Feng; Juan Chen; Jiahao Liu; Jianmin Wu; Hongpei Tan; Ze Mi; Pengfei Rong

doi:10.3389/fimmu.2023.1134636

Controversial role of ILC3s in intestinal diseases: A novelty perspective on immunotherapy

Front Immunol. 2023 Mar 28:14:1134636. doi: 10.3389/fimmu.2023.1134636. eCollection 2023.

Authors

Yunshu Zhang^{1

2}, Xuefei Feng³, Juan Chen¹, Jiahao Liu¹, Jianmin Wu¹, Hongpei Tan¹, Ze Mi¹, Pengfei Rong^{1

4}

Affiliations

¹ Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Xiangya School of Medicine, Central South University, Changsha, China.
³ Department of Government & Public Administration, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
⁴ Key Laboratory of Biological Nanotechnology of National Health Commission, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Abstract

ILC3s have been identified as crucial immune regulators that play a role in maintaining host homeostasis and modulating the antitumor response. Emerging evidence supports the idea that LTi cells play an important role in initiating lymphoid tissue development, while other ILC3s can promote host defense and orchestrate adaptive immunity, mainly through the secretion of specific cytokines and crosstalk with other immune cells or tissues. Additionally, dysregulation of ILC3-mediated overexpression of cytokines, changes in subset abundance, and conversion toward other ILC subsets are closely linked with the occurrence of tumors and inflammatory diseases. Regulation of ILC3 cytokines, ILC conversion and LTi-induced TLSs may be a novel strategy for treating tumors and intestinal or extraintestinal inflammatory diseases. Herein, we discuss the development of ILCs, the biology of ILC3s, ILC plasticity, the correlation of ILC3s and adaptive immunity, crosstalk with the intestinal microenvironment, controversial roles of ILC3s in intestinal diseases and potential applications for treatment.

Keywords: cancer; inflammatory disease; innate lymphocyte cell; intestine homeostasis; plasticity; secondary lymphoid organ; tertiary lymphoid tissue; transcription factor.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cytokines
Humans
Immunity, Innate
Immunotherapy
Intestinal Diseases*
Lymphocytes
Neoplasms*
Tumor Microenvironment

Substances

Cytokines

Grants and funding

This work was supported by the National Natural Science Foundation of China (No. 81201986) the Science and Technology Project of Hunan Province (2021RC4017), the Furong Scholars Programme of Hunan Province and the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University.