Pathogenesis and therapy of radiation enteritis with gut microbiota

Qilin Yang; Bingzhi Qin; Weiliang Hou; Huanlong Qin; Fang Yin

doi:10.3389/fphar.2023.1116558

Pathogenesis and therapy of radiation enteritis with gut microbiota

Front Pharmacol. 2023 Mar 31:14:1116558. doi: 10.3389/fphar.2023.1116558. eCollection 2023.

Authors

Qilin Yang^{1

2}, Bingzhi Qin¹, Weiliang Hou^{1

3}, Huanlong Qin¹, Fang Yin¹

Affiliations

¹ Research Institute of Intestinal Diseases, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
² School of Clinical Medicine of Nanjing Medical University, Nanjing, China.
³ Shanghai Cancer Institute, Renji Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Abstract

Radiotherapy is widely used in clinic due to its good effect for cancer treatment. But radiotherapy of malignant tumors in the abdomen and pelvis is easy to cause radiation enteritis complications. Gastrointestinal tract contains numerous microbes, most of which are mutualistic relationship with the host. Abdominal radiation results in gut microbiota dysbiosis. Microbial therapy can directly target gut microbiota to reverse microbiota dysbiosis, hence relieving intestinal inflammation. In this review, we mainly summarized pathogenesis and novel therapy of the radiation-induced intestinal injury with gut microbiota dysbiosis and envision the opportunities and challenges of radiation enteritis therapy.

Keywords: gut microbiota; microbial therapy; pathogenesis; radiation enteritis; radiotherapy.

Publication types

Review

Grants and funding

This work was financially supported by the National Natural Science Foundation of China (32100070; 81730102), the Science and Technology Commission of Shanghai Municipality (YDZX20213100003690), the Shanghai Municipal Health Commission (ZHYY-ZXYJHZX-202105), the Hospital Development Center (SHDC2022CRS041), and the supported by the Fundamental Research Funds for the Central Universities (22120220607).