The role of extracellular vesicles in cancer

Raghu Kalluri; Kathleen M McAndrews

doi:10.1016/j.cell.2023.03.010

The role of extracellular vesicles in cancer

Cell. 2023 Apr 13;186(8):1610-1626. doi: 10.1016/j.cell.2023.03.010.

Authors

Raghu Kalluri¹, Kathleen M McAndrews²

Affiliations

¹ Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. Electronic address: rkalluri@mdanderson.org.
² Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. Electronic address: kmmcandrews@mdanderson.org.

Abstract

Intercellular communication is a key feature of cancer progression and metastasis. Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent studies have identified EVs as key mediators of cell-cell communication via packaging and transfer of bioactive constituents to impact the biology and function of cancer cells and cells of the tumor microenvironment. Here, we review recent advances in understanding the functional contribution of EVs to cancer progression and metastasis, as cancer biomarkers, and the development of cancer therapeutics.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Biomarkers, Tumor
Cell Communication / physiology
Extracellular Vesicles*
Humans
Neoplasms* / pathology
Tumor Microenvironment / physiology

Substances

Biomarkers, Tumor

Abstract

Publication types

MeSH terms

Substances

Grants and funding