Photoinduced Cascade Difluoroalkylative Ring-Opening of Vinyl Cyclopropanes

Org Lett. 2023 Apr 28;25(16):2857-2862. doi: 10.1021/acs.orglett.3c00820. Epub 2023 Apr 14.

Abstract

Here, we report a facile and efficient method for the difluoroalkylation of vinyl cyclopropanes (VCPs) using visible-light organophotoredox catalysis. This strategy exploits the interplay of α-amino alkyl radical-mediated halogen-atom transfer (XAT) reaction. The broad substrate scope, excellent functional group compatibility, operational simplicity, inexpensive CF2 precursors, and high efficiency make this protocol promising for the cost-efficient synthesis of allylic difluoroalkylated derivatives.