The composite phenotype analysis identifies potential concerted responses of physiological systems to high altitude exposure

Natl Sci Rev. 2023 Mar 1;10(5):nwad053. doi: 10.1093/nsr/nwad053. eCollection 2023 May.

Yi Li^{1

2

3}, Meng Hao^{4

5}, Zixin Hu^{4

6}, Yanyun Ma^{4

2}, Kun Wang⁴, Xiaoyu Liu¹, Xianhong Yin¹, Menghan Zhang⁴, Yi Wang⁴, Meng Liang⁴, Yuan Guo⁴, Lei Bao⁴, Shixuan Zhang⁴, Shiguan Le¹, Chenyuan Wu¹, Dayan Sun¹, Yang Wei¹, Fei Wu⁴, Rui Zhang^{1

2}, Lingxian Zhu⁴, Hui Zhang⁴, Shuai Jiang^{4

7}, Xingdong Chen^{1

8}, Xiaofeng Wang¹, Yao Zhang⁹, Longli Kang⁹, Wenyuan Duan¹⁰, Bin Qiao¹⁰, Jiucun Wang^{1

2

11}, Li Jin^{1

2

11

3}

¹ State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, China.
² Institute for Six-sector Economy, Fudan University, China.
³ International Human Phenome Institutes, China.
⁴ Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, China.
⁵ Greater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences, Fudan University, China.
⁶ Artificial Intelligence Innovation and Incubation Institute, Fudan University, China.
⁷ Shanghai Pudong Hospital, Fudan University Pudong Medical Center, China.
⁸ Fudan-Taizhou Institute of Health Sciences, China.
⁹ Key Laboratory of High-Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, China.
¹⁰ Institute of Cardiovascular Disease, Shandong Provincial Western Hospital, China.
¹¹ Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058), Chinese Academy of Medical Sciences, China.

No abstract available