Immune Reconstitution and Vaccinations in Multiple Myeloma: A Report From the 19th International Myeloma Society Annual Workshop

Evangelos Terpos; Paola Neri; Niels W C J van de Donk; Mattia D'Agostino; Samir Parekh; Sundar Jagannath; Heinz Ludwig; David E Avigan; Madhav V Dhodapkar; Noopur S Raje

doi:10.1016/j.clml.2023.03.009

Immune Reconstitution and Vaccinations in Multiple Myeloma: A Report From the 19th International Myeloma Society Annual Workshop

Clin Lymphoma Myeloma Leuk. 2023 Jun;23(6):413-419. doi: 10.1016/j.clml.2023.03.009. Epub 2023 Mar 23.

Authors

Affiliations

¹ Department of Clinical Therapeutics, Plasma Cell Dyscrasias Unit, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
² Department of Medical Oncology and Hematology, Tom Baker Cancer Center, Calgary, Alberta, Canada; Arnie Charbonneau Cancer Research Institute, Calgary, Alberta, Canada.
³ Department of Hematology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Cancer Biology and Immunology, Cancer Center Amsterdam, Amsterdam, the Netherlands.
⁴ SSD Clinical Trial in Oncoematologia e Mieloma Multiplo, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.
⁵ Department of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
⁶ Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
⁷ Department of Medicine I, Center for Medical Oncology and Hematology with Outpatient Department and Palliative Care, Wilhelminen Cancer Research Institute, Vienna, Austria.
⁸ Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
⁹ Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA.
¹⁰ Cellular Immunotherapy Program, Massachusetts General Hospital, Boston, MA; Center for Multiple Myeloma, Massachusetts General Hospital, Boston, MA. Electronic address: nraje@mgh.harvard.edu.

PMID: 37055346
DOI: 10.1016/j.clml.2023.03.009

Abstract

Given the significance of the immune system and the important role of therapies within the context of the immune system in plasma cell disorders, the International Myeloma Society annual workshop convened a session dedicated to this topic. A panel of experts covered various aspects of immune reconstitution and vaccination. The top oral presentations were highlighted and discussed. This is a report of the proceedings.

Keywords: B-cell; Bispecific; CAR T-cell; Immune response; T-cell.

Publication types

Review

MeSH terms

Humans
Immune Reconstitution*
Immunotherapy, Adoptive
Multiple Myeloma* / therapy
Vaccination