Insights into the co-evolution of epithelial cells and fibroblasts in the esophageal tumor microenvironment

Hagar Lavon; Ruth Scherz-Shouval

doi:10.1016/j.ccell.2023.03.020

Insights into the co-evolution of epithelial cells and fibroblasts in the esophageal tumor microenvironment

Cancer Cell. 2023 May 8;41(5):826-828. doi: 10.1016/j.ccell.2023.03.020. Epub 2023 Apr 12.

Authors

Hagar Lavon¹, Ruth Scherz-Shouval²

Affiliations

¹ Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
² Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel. Electronic address: ruth.shouval@weizmann.ac.il.

PMID: 37054715
DOI: 10.1016/j.ccell.2023.03.020

Abstract

Cancer-associated fibroblasts (CAFs) are recruited and rewired by cancer cells to become protumorigenic. The molecular mechanisms underlying this crosstalk in esophageal cancer are completely unknown. Chen et al. discover that premalignant epithelial cells of the esophagus rewire normal resident fibroblasts into CAFs through the downregulation of ANXA1-FRP2 signaling.

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MeSH terms

Epithelial Cells
Esophageal Neoplasms* / genetics
Fibroblasts
Humans
Tumor Microenvironment*