Role of CD34 in inflammatory bowel disease

Zhiyuan Li; Shuyan Dong; Shichen Huang; Yuhan Sun; Yingzhi Sun; Beibei Zhao; Qiulan Qi; Lei Xiong; Feng Hong; Yuxin Jiang

doi:10.3389/fphys.2023.1144980

Role of CD34 in inflammatory bowel disease

Front Physiol. 2023 Mar 27:14:1144980. doi: 10.3389/fphys.2023.1144980. eCollection 2023.

Authors

Zhiyuan Li^{1

2}, Shuyan Dong¹, Shichen Huang², Yuhan Sun², Yingzhi Sun¹, Beibei Zhao², Qiulan Qi¹, Lei Xiong³, Feng Hong⁴, Yuxin Jiang¹

Affiliations

¹ Jiaxing Key Laboratory of Virus-Related Infectious Diseases, The Affiliated Hospital of Jiaxing University, Jiaxing University College of Medicine, Jiaxing, Zhejiang, China.
² School of Pharmacy, Wannan Medical College, Wuhu, Anhui, China.
³ Department of Biochemistry and Molecular Biology, Wannan Medical College, Wuhu, Anhui, China.
⁴ The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.

Abstract

Inflammatory bowel disease (IBD) is caused by a variety of pathogenic factors, including chronic recurrent inflammation of the ileum, rectum, and colon. Immune cells and adhesion molecules play an important role in the course of the disease, which is actually an autoimmune disease. During IBD, CD34 is involved in mediating the migration of a variety of immune cells (neutrophils, eosinophils, and mast cells) to the inflammatory site, and its interaction with various adhesion molecules is involved in the occurrence and development of IBD. Although the function of CD34 as a partial cell marker is well known, little is known on its role in IBD. Therefore, this article describes the structure and biological function of CD34, as well as on its potential mechanism in the development of IBD.

Keywords: CD34; adhesion molecules; immune cells; inflammatory bowel disease; integrin; selectin.

Publication types

Review

Grants and funding

This research was supported by Natural Science Foundation of Anhui Province (1708085QH206), National Natural Science Foundation of China (81671586 and 81270091), Research Start-up Fund Project of Jiaxing University for Introducing Talents (No. CD70519066), and the Municipal Public Welfare Research Project (2022AY10001) from Jiaxing, Zhejiang, China.