Endogenous stimulus-controlled estradiol@AIEgen-based covalent organic framework for reduction of myocardial ischemia/reperfusion injury

Fang Yuan; Cuiling Zhang; Xianzhu Luo; Xiaokun Shen; Yuezhong Xian

doi:10.1039/d3cc00799e

Endogenous stimulus-controlled estradiol@AIEgen-based covalent organic framework for reduction of myocardial ischemia/reperfusion injury

Chem Commun (Camb). 2023 Apr 25;59(34):5122-5125. doi: 10.1039/d3cc00799e.

Authors

Fang Yuan¹, Cuiling Zhang¹, Xianzhu Luo¹, Xiaokun Shen², Yuezhong Xian¹

Affiliations

¹ Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China. clzhang@chem.ecnu.edu.cn.
² Convalife (Shanghai) Co. Ltd., Shanghai 201203, China.

PMID: 37039428
DOI: 10.1039/d3cc00799e

Abstract

ATP stimulus-responsive tetrahedral DNA-gated fluorescent covalent organic frameworks (COFs) were developed for estradiol (E2) delivery and controllable release. The fluorescent COFs with an efficient E2 loading showed great potential against myocardial ischemia and reperfusion injury.

MeSH terms

Coloring Agents
Estradiol
Humans
Metal-Organic Frameworks* / pharmacology
Myocardial Reperfusion Injury*

Substances

Estradiol
Metal-Organic Frameworks
Coloring Agents