Mannose-coated nanozyme for relief from chemotherapy-induced peripheral neuropathic pain

Hu Liu; Xin Qing; Lijun Peng; Ding Zhang; Wei Dai; Zhilai Yang; Jiqian Zhang; Xuesheng Liu

doi:10.1016/j.isci.2023.106414

Mannose-coated nanozyme for relief from chemotherapy-induced peripheral neuropathic pain

iScience. 2023 Mar 17;26(4):106414. doi: 10.1016/j.isci.2023.106414. eCollection 2023 Apr 21.

Authors

Hu Liu¹, Xin Qing¹, Lijun Peng¹, Ding Zhang¹, Wei Dai¹, Zhilai Yang¹, Jiqian Zhang¹, Xuesheng Liu¹

Affiliation

¹ Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui Province 20032, China.

Abstract

Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a progressive and disturbing peripheral neuropathy with currently no effective treatment. Aberrant production of reactive oxygen species (ROS) in macrophages near peripheral nerves plays a dominant role in CIPNP; however, traditional ROS scavengers have difficulty maintaining viability to target macrophages in vivo. Mannose-coated superparamagnetic iron oxide nanoparticles (mSPIONs) were synthesized to treat CIPNP. The anti-ROS and anti-inflammatory effects of mSPIONs were assessed in J774A.1 cells and sciatic nerves in a nociception mouse model induced with vincristine (VCR). We found that the mSPIONs significantly reduced ROS levels in vitro and in vivo. Furthermore, mSPIONs administration specifically reduced IL-6 and TNF-α levels in macrophages near the sciatic nerve and relieved VCR-induced peripheral neuropathic pain. Inhibition of the VCR-upregulated HIF1α/NF-κB signaling pathway may be involved in the alleviation of inflammation. These results provide a new approach for relieving CIPNP using a nanozyme.

Keywords: Immunology; Molecular physiology; Nanotechnology; Neuroscience.