The emerging role of ferroptosis in myocardial fibrosis of atrial fibrillation

Honghua Yue; Yujia Zhan; Zheng Zhang; Weitao Liang; Zhong Wu

doi:10.5114/aoms/160941

The emerging role of ferroptosis in myocardial fibrosis of atrial fibrillation

Arch Med Sci. 2023 Feb 24;19(2):507-512. doi: 10.5114/aoms/160941. eCollection 2023.

Authors

Honghua Yue¹, Yujia Zhan¹, Zheng Zhang¹, Weitao Liang¹, Zhong Wu¹

Affiliation

¹ Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China.

Abstract

Introduction: The aim of this study was to investigate the relationship between ferroptosis and myocardial fibrosis in atrial fibrillation (AF).

Methods: The patient's left atrial appendage tissue was obtained in cardiac surgery. Sirius red staining, Prussian blue and Western blot were used to detect staining to assess histological fibrosis and ferroptosis changes.

Results: There is a certain correlation between the degree of tissue fibrosis and ferroptosis in AF (r = 0.7763, p = 0.0004). The key proteins related to the regulation of ferroptosis were significantly abnormal in the AF group.

Conclusions: Ferroptosis is involved in myocardial fibrosis of AF and is a potential target for the diagnosis, prevention and treatment of AF.

Keywords: atrial fibrillation; ferroptosis; myocardial fibrosis.