Palladium-Mediated Synthesis of 2-([Biphenyl]-4-yloxy)quinolin-3-carbaldehydes through Suzuki-Miyaura Cross-Coupling and Their in Silico Breast Cancer Studies on the 3ERT Protein

Peruru Hemanth Kumar; Majji Rambabu; Vijayaparthasarathi Vijayakumar; Sundaramoorthy Sarveswari

doi:10.1021/acsomega.2c06418

Palladium-Mediated Synthesis of 2-([Biphenyl]-4-yloxy)quinolin-3-carbaldehydes through Suzuki-Miyaura Cross-Coupling and Their in Silico Breast Cancer Studies on the 3ERT Protein

ACS Omega. 2023 Mar 21;8(13):11806-11812. doi: 10.1021/acsomega.2c06418. eCollection 2023 Apr 4.

Authors

Peruru Hemanth Kumar¹, Majji Rambabu², Vijayaparthasarathi Vijayakumar¹, Sundaramoorthy Sarveswari¹

Affiliations

¹ Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India.
² Department of Biotechnology, REVA University, Bangalore 560064, India.

Abstract

A series of novel quinoline appended biaryls have been synthesized (5a-5o) by reacting various substituted boronic acids (4e-4h) with various substituted 2-(4-bromophenoxy)quinolin-3-carbaldehydes (3a-3d) through carbon-carbon bond formation. Effects of various quinoline appended biaryls (5a-5o) on the breast cancer protein 3ERT are moderate to high, as found by in silico molecular docking studies. Comparatively, all quinoline appended biaryls (5a-5o) 5h show better efficacy with a binding energy of -9.39 kcal/mol, and hydrogen bonds are Thr347, Glu353, and Arg394 in the binding pocket. Conclusively, the final novel quinoline appended biaryls (5a-5o) have been confirmed with all the spectral studies, and their efficacy has been validated with in silico studies.