SARS-CoV-2 N protein induces acute kidney injury in diabetic mice via the Smad3-Ripk3/MLKL necroptosis pathway

Liying Liang; Wenbiao Wang; Junzhe Chen; Wenjing Wu; Xiao-Ru Huang; Biao Wei; Yu Zhong; Ronald C W Ma; Xueqing Yu; Hui-Yao Lan

doi:10.1038/s41392-023-01410-x

SARS-CoV-2 N protein induces acute kidney injury in diabetic mice via the Smad3-Ripk3/MLKL necroptosis pathway

Signal Transduct Target Ther. 2023 Apr 7;8(1):147. doi: 10.1038/s41392-023-01410-x.

Authors

Liying Liang^{1

2

3}, Wenbiao Wang^{3

4}, Junzhe Chen^{1

5}, Wenjing Wu^{1

3

4}, Xiao-Ru Huang^{1

3

4}, Biao Wei¹, Yu Zhong¹, Ronald C W Ma¹, Xueqing Yu^{6

7}, Hui-Yao Lan^{8

9

10}

Affiliations

¹ Departments of Medicine & Therapeutics, Li Ka Shing Institute of Health Sciences, and Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, China.
² Department of Clinical Pharmacy, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
³ The Chinese University of Hong Kong-Guangdong Academy of Sciences/Guangdong Provincial People's Hospital Joint Research Laboratory on Immunological and Genetic Kidney Diseases, The Chinese University of Hong Kong, Hong Kong, China.
⁴ Guangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Disease and Medical Research Center, and Departments of Nephrology and Pathology, Guangdong Academy of Medical Science, Guangdong Provincial People's Hospital, Guangzhou, China.
⁵ Department of Nephrology, The Third Affiliated hospital, Southern Medical University, Guangzhou, China.
⁶ The Chinese University of Hong Kong-Guangdong Academy of Sciences/Guangdong Provincial People's Hospital Joint Research Laboratory on Immunological and Genetic Kidney Diseases, The Chinese University of Hong Kong, Hong Kong, China. yuxueqing@gdph.org.cn.
⁷ Guangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Disease and Medical Research Center, and Departments of Nephrology and Pathology, Guangdong Academy of Medical Science, Guangdong Provincial People's Hospital, Guangzhou, China. yuxueqing@gdph.org.cn.
⁸ Departments of Medicine & Therapeutics, Li Ka Shing Institute of Health Sciences, and Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, China. hylan@cuhk.edu.hk.
⁹ The Chinese University of Hong Kong-Guangdong Academy of Sciences/Guangdong Provincial People's Hospital Joint Research Laboratory on Immunological and Genetic Kidney Diseases, The Chinese University of Hong Kong, Hong Kong, China. hylan@cuhk.edu.hk.
¹⁰ Guangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Disease and Medical Research Center, and Departments of Nephrology and Pathology, Guangdong Academy of Medical Science, Guangdong Provincial People's Hospital, Guangzhou, China. hylan@cuhk.edu.hk.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Acute Kidney Injury* / genetics
Animals
COVID-19*
Diabetes Mellitus, Experimental*
Mice
Necroptosis / genetics
Protein Kinases / metabolism
Receptor-Interacting Protein Serine-Threonine Kinases / metabolism
SARS-CoV-2 / metabolism

Substances

Ripk3 protein, mouse
Receptor-Interacting Protein Serine-Threonine Kinases
MLKL protein, mouse
Protein Kinases