Hepatocellular carcinoma (HCC) is the most common primary liver malignancy with worldwide high incidence and mortality. In more than 90% of cases, HCC arise from a cirrhotic liver that is mostly induced by viral diseases and especially in developed countries alcoholic steatohepatitis and non-alcoholic steatohepatitis. In contrast, cholangiocellular carcinoma (CCC) is a very rare cancer entity with a high mortality due to insidious onset. The only curative option for both cancer entities is a timely and definitive surgical therapy, which mandates an accurate early diagnosis. To this end, [18F]FDG PET/CT scan could demonstrate only little benefit, as there is an unmet clinical need for an alternative, pan-cancer agent for initial diagnostic work-up of CCC or evaluation of Milan criteria for HCC patients.
Keywords: Cholangiocellular carcinoma; FAP imaging; FAPI PET; Fibroblast activation protein; Hepatocellular carcinoma.
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