Updated experimental cellular models to study polycystic ovarian syndrome

Gokul Sudhakaran; Sarvesh Ramesh Babu; Hridai Mahendra; Jesu Arockiaraj

doi:10.1016/j.lfs.2023.121672

Updated experimental cellular models to study polycystic ovarian syndrome

Life Sci. 2023 Jun 1:322:121672. doi: 10.1016/j.lfs.2023.121672. Epub 2023 Apr 5.

Authors

Gokul Sudhakaran¹, Sarvesh Ramesh Babu¹, Hridai Mahendra¹, Jesu Arockiaraj²

Affiliations

¹ Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, 603 203 Chennai, Tamil Nadu, India.
² Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, 603 203 Chennai, Tamil Nadu, India. Electronic address: jesuaroa@srmist.edu.in.

PMID: 37028548
DOI: 10.1016/j.lfs.2023.121672

Abstract

Polycystic ovarian syndrome (PCOS) develops due to hormonal imbalance and hyperandrogenism. Animal models are widely used to study PCOS because they mimic essential characteristics of human PCOS; however, the pathogenesis of PCOS remains unclear. Different sources of novel drugs are currently being screened as therapeutic strategies to alleviate PCOS and its symptoms. Simplified cell line in-vitro models could be preliminarily used to screen the bioactivity of various drugs. This review describes different cell line models focusing on the PCOS condition and its complications. Therefore, the bioactivity of the drugs could be preliminarily screened in a cell line model before moving to higher animal models.

Keywords: Cellular models; Hormonal imbalance; In-vitro model; Ovarian dysfunction; Polycystic ovarian syndrome (PCOS).

Publication types

Review

MeSH terms

Animals
Female
Humans
Hyperandrogenism* / pathology
Polycystic Ovary Syndrome* / metabolism