Splice epitranscriptomics and DNA damage repair together: ALKBH5-m6A-SF3B1 regulation in leukemic transformation

Zhongyu Zou; Chuan He

doi:10.1016/j.molcel.2023.02.019

Splice epitranscriptomics and DNA damage repair together: ALKBH5-m⁶A-SF3B1 regulation in leukemic transformation

Mol Cell. 2023 Apr 6;83(7):1022-1023. doi: 10.1016/j.molcel.2023.02.019.

Authors

Zhongyu Zou¹, Chuan He²

Affiliations

¹ Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.
² Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA; Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA. Electronic address: chuanhe@uchicago.edu.

PMID: 37028412
DOI: 10.1016/j.molcel.2023.02.019

Abstract

In this issue, Cieśla et al.¹ report a translation regulation through ALKBH5-mediated 5'-UTR m⁶A demethylation of the SF3B1 transcript during leukemic transformation. The SF3B1 protein maintains efficient splicing and expression of transcripts encoding DNA damage repair components to restrain excessive DNA damage.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

DNA Damage / genetics
Mutation
Phosphoproteins* / genetics
RNA Splicing Factors / genetics
RNA Splicing* / genetics

Substances

RNA Splicing Factors
Phosphoproteins

Grants and funding

R01 ES030546/ES/NIEHS NIH HHS/United States