Chemical reprogramming takes the fast lane

Emily J Park; Srikanth Kodali; Bruno Di Stefano

doi:10.1016/j.stem.2023.03.001

Chemical reprogramming takes the fast lane

Cell Stem Cell. 2023 Apr 6;30(4):335-337. doi: 10.1016/j.stem.2023.03.001.

Authors

Emily J Park¹, Srikanth Kodali¹, Bruno Di Stefano²

Affiliations

¹ Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.
² Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA. Electronic address: bruno.distefano@bcm.edu.

PMID: 37028396
DOI: 10.1016/j.stem.2023.03.001

Abstract

Small molecule-induced cell fate transitions are characterized by low efficiency and slow kinetics. An optimized chemical reprogramming approach now facilitates the robust and rapid conversion of somatic cells to pluripotent stem cells, unlocking exciting avenues to study and manipulate human cell identity.

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MeSH terms

Cell Differentiation
Cellular Reprogramming
Humans
Induced Pluripotent Stem Cells*
Pluripotent Stem Cells*