This work presents an artificial intelligence (AI) framework for real-time, personalized sepsis prediction four hours before onset through fusion of electrocardiogram (ECG) and patient electronic medical record. An on-chip classifier combines analog reservoir-computer and artificial neural network to perform prediction without front-end data converter or feature extraction which reduces energy by 13× compared to digital baseline at normalized power efficiency of 528 TOPS/W, and reduces energy by 159× compared to RF transmission of all digitized ECG samples. The proposed AI framework predicts sepsis onset with 89.9% and 92.9% accuracy on patient data from Emory University Hospital and MIMIC-III respectively. The proposed framework is non-invasive and does not require lab tests which makes it suitable for at-home monitoring.