Dental health of patients with X-linked hypophosphatemia: A controlled study

Amila Larsson; Tobias Regnstrand; Pia Skott; Outi Mäkitie; Sigridur Björnsdottir; Karin Garming-Legert

doi:10.3389/froh.2023.1087761

Dental health of patients with X-linked hypophosphatemia: A controlled study

Front Oral Health. 2023 Mar 21:4:1087761. doi: 10.3389/froh.2023.1087761. eCollection 2023.

Authors

Amila Larsson^{1

2}, Tobias Regnstrand¹, Pia Skott^{1

2}, Outi Mäkitie^{3

4

5}, Sigridur Björnsdottir^{5

6}, Karin Garming-Legert¹

Affiliations

¹ Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
² Public Dental Health Service Stockholm AB, Stockholm, Sweden.
³ Department of Pediatric Research, Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
⁴ Department of Clinical Genetics, Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
⁵ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
⁶ Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.

Abstract

Objective: The present study compared the dental health of patients with X-linked hypophosphatemia (XLH) with healthy age- and gender-matched controls to increase our knowledge of the impact of XLH on oral health.

Materials and methods: Twenty-two adult patients with XLH in the Stockholm region of Sweden were referred to the Department of Orofacial Medicine at Karolinska Institutet for an extended clinical and radiological examination. Pre-existing radiologic examinations of 44 healthy age- and gender-matched controls were retrieved from the Department of Oral Radiology, at Karolinska Institutet.

Results: The 22 patients with XLH (15 females, median age 38 years, range 20-71; 7 males, median age 49 years, range 24-67) had a significantly higher number of root-filled teeth compared to healthy controls (p = .001). In the XLH group, females had significantly better oral health than males, especially concerning endodontic and cariological status (p's = .01 and .02, respectively). Periodontal status differed non-significantly between the XLH and control groups.

Conclusion: Patients with XLH had a significantly lower oral health status compared to a healthy population especially concerning endodontic conditions. Male patients with XLH had a higher risk of poor oral health compared to female patients with XLH.

Keywords: XLH; dental; endodontic; infections; periodontal.

Grants and funding

This project was supported by funding from the Public Dental Health Service Stockholm AB, Stockholm, Sweden, and the Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.