Ferroptosis: Mechanism and potential applications in cervical cancer

Xiangyu Chang; Jinwei Miao

doi:10.3389/fmolb.2023.1164398

Ferroptosis: Mechanism and potential applications in cervical cancer

Front Mol Biosci. 2023 Mar 21:10:1164398. doi: 10.3389/fmolb.2023.1164398. eCollection 2023.

Authors

Xiangyu Chang¹, Jinwei Miao¹

Affiliation

¹ Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

Abstract

Ferroptosis is a distinct form of cell death mechanism different from the traditional ones. Ferroptosis is characterized biochemically by lipid peroxidation, iron accumulation, and glutathione deficiency. It has already demonstrated significant promise in antitumor therapy. Cervical cancer (CC) progression is closely linked to iron regulation and oxidative stress. Existing research has investigated the role of ferroptosis in CC. Ferroptosis could open up a new avenue of research for treating CC. This review will describe the factors and pathways and the research basis of ferroptosis, which is closely related to CC. Furthermore, the review may provide potential future directions for CC research, and we believe that more studies concerning the therapeutic implications of ferroptosis in CC will come to notice.

Keywords: cervical cancer; ferroptosis; iron accumulation; lipid peroxidation; treatment.

Publication types

Review

Grants and funding

National Natural Science Foundation of China, No. 82271677 Beijing Hospitals Authority’s Ascent Plan, Code: DFL20221201; Beijing Municipal Health Commission, demonstration construction project of Clinical Research ward (NO: BCRW202109); Gynecological Tumor Precise Diagnosis and Treatment Innovaticn Studio; Funds received for open access publication fees from Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital.