Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities

Jorge de Lima Neto; Paulo Henrique Menezes

doi:10.3762/bjoc.19.31

Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities

Beilstein J Org Chem. 2023 Mar 29:19:399-427. doi: 10.3762/bjoc.19.31. eCollection 2023.

Authors

Jorge de Lima Neto^#¹, Paulo Henrique Menezes^#¹

Affiliation

¹ Universidade Federal de Pernambuco, Departamento de Química Fundamental, Recife-PE, 50740-560, Brazil.

^# Contributed equally.

Abstract

The combretastatin D series and its analogues, corniculatolides and isocorniculatolides belong to a class of macrocycles called cyclic diaryl ether heptanoids (DAEH). This review is intended to highlight the structure elucidation, biosynthesis, and biological activity of these compounds as well as the use of different strategies for their synthesis.

Keywords: combretastatin D; corniculatolide; isocorniculatolide; macrocycles.

Publication types

Review

Grants and funding

We gratefully acknowledge CAPES, CNPq and FACEPE (APQ-0549-1.06/17/INCT 2014) for financial support. P. H. M (302829/2022-9) and J. L. N. (IBPG-0252-1.06/20) are also thankful to CNPq and FACEPE for their fellowships.