Vaccination against Helicobacter pylori - An approach for cancer prevention?

Verena Friedrich; Markus Gerhard

doi:10.1016/j.mam.2023.101183

Vaccination against Helicobacter pylori - An approach for cancer prevention?

Mol Aspects Med. 2023 Aug:92:101183. doi: 10.1016/j.mam.2023.101183. Epub 2023 Apr 3.

Authors

Verena Friedrich¹, Markus Gerhard²

Affiliations

¹ Technical University of Munich (TUM), School of Medicine, Institute for Medical Microbiology, Immunology and Hygiene, Trogerstrasse 30, Munich 81675, Germany.
² Technical University of Munich (TUM), School of Medicine, Institute for Medical Microbiology, Immunology and Hygiene, Trogerstrasse 30, Munich 81675, Germany. Electronic address: markus.gerhard@tum.de.

PMID: 37018869
DOI: 10.1016/j.mam.2023.101183

Abstract

The gram-negative bacterium Helicobacter pylori is the most common chronic bacterial infection and the main cause of gastric cancer. Due to the increasing antimicrobial resistance of H. pylori, the development of an efficacious vaccine is a valid option to protect from disease or infection and ultimately prevent gastric cancer. However, despite more than 30 years of research, no vaccine has entered the market yet. This review highlights the most relevant previous preclinical and clinical studies to allow conclusions to be drawn on which parameters need special attention in the future to develop an efficacious vaccine against H. pylori and thus prevent gastric cancer.

Keywords: Gastric cancer; Helicobacter pylori; Vaccine.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Vaccines / therapeutic use
Helicobacter Infections* / complications
Helicobacter Infections* / prevention & control
Helicobacter pylori*
Humans
Stomach Neoplasms* / drug therapy
Stomach Neoplasms* / microbiology
Stomach Neoplasms* / prevention & control
Vaccination

Substances

Bacterial Vaccines