[18F]FE-PE2I DAT correlates with Parkinson's disease duration, stage, and rigidity/bradykinesia scores: a PET radioligand validation study

Vera S Kerstens; Patrik Fazio; Mathias Sundgren; Christer Halldin; Per Svenningsson; Andrea Varrone

doi:10.1186/s13550-023-00974-7

[¹⁸F]FE-PE2I DAT correlates with Parkinson's disease duration, stage, and rigidity/bradykinesia scores: a PET radioligand validation study

EJNMMI Res. 2023 Apr 5;13(1):29. doi: 10.1186/s13550-023-00974-7.

Authors

Vera S Kerstens¹, Patrik Fazio², Mathias Sundgren³, Christer Halldin², Per Svenningsson³, Andrea Varrone²

Affiliations

¹ Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm Health Care Services, Stockholm, Sweden. vera.kerstens@ki.se.
² Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm Health Care Services, Stockholm, Sweden.
³ Department of Clinical Neuroscience, Neuro Department, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

Abstract

Background: Correlations between dopamine transporter (DAT) availability and Parkinson's disease (PD) motor symptoms vary depending on the imaging modality, choice of regions of interest and clinical measures. We aimed to validate the PET radioligand [¹⁸F]FE-PE2I as a clinical biomarker in PD, hypothesizing negative correlations between DAT availability in specified nigrostriatal regions with symptom duration, disease stage and motor symptom scores.

Methods: We included 41 PD patients (age 45-79 years; H&Y stage < 3) and 37 healthy control subjects in a cross-sectional study with dynamic [¹⁸F]FE-PE2I PET. Binding potential (BP_ND) was estimated in the caudate nucleus, putamen, ventral striatum, sensorimotor striatum, and substantia nigra using the cerebellum as reference region.

Results: We found negative correlations (p < 0.02) between symptom duration and BP_ND in the putamen and sensorimotor striatum (r_s = - .42; r_s = - .51), and between H&Y stage and BP_ND in caudate nucleus, putamen, sensorimotor striatum, and substantia nigra (r_s between - .40 and - .54). The first correlations were better described with exponential fitting. MDS-UPDRS-III in 'OFF' state correlated negatively (p < 0.04) with BP_ND in the sensorimotor striatum (r_s = - .47), and excluding tremor score also in the putamen (r_s = - .45).

Conclusion: Results are in agreement with earlier findings in in vivo and post-mortem studies and validate [¹⁸F]FE-PE2I as a functional PD biomarker for PD severity.

Trial registration: EudraCT 2011-0020050, Registered April 26 2011; EudraCT 2017-003327-29, Registered October 08 2017; EudraCT 2017-001585-19, Registered August 2 2017. https://eudract.ema.europa.eu/ .

Keywords: DAT; Disease duration; Motor scores; Parkinson’s disease; [18F]FE-PE2I.