Repurposing picropodophyllin as a potential thyroid eye disease treatment via delaying mitotic clonal expansion through a patient-derived preclinical platform

Jing Hu; Jiali Wu; Qihuang Jin; Ling Zhang; Ning Shen; Yiyang Shu; Lu Cheng; Jian Zhang; Guangyi Hu; Kangjia Lv; Qizhi Jian; Hui Chen; Fang Zhang; Xiaodong Sun

doi:10.1002/ctm2.1218

Repurposing picropodophyllin as a potential thyroid eye disease treatment via delaying mitotic clonal expansion through a patient-derived preclinical platform

Clin Transl Med. 2023 Apr;13(4):e1218. doi: 10.1002/ctm2.1218.

Authors

Jing Hu^{1

2}, Jiali Wu^{1

2}, Qihuang Jin^{1

2}, Ling Zhang^{1

2}, Ning Shen^{1

2}, Yiyang Shu^{1

2}, Lu Cheng^{1

2}, Jian Zhang^{1

2}, Guangyi Hu^{1

2}, Kangjia Lv^{1

2}, Qizhi Jian^{1

2}, Hui Chen^{1

2

3

4

5

6

7}, Fang Zhang^{1

2

3

4}, Xiaodong Sun^{1

2

3

4}

Affiliations

¹ National Clinical Research Center for Eye Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Shanghai Key Laboratory of Fundus Diseases, Shanghai, China.
³ Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.
⁴ Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.
⁵ School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
⁶ Eye School of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
⁷ University of Shanghai for Science and Technology, Shanghai, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adipocytes
Graves Ophthalmopathy*
Humans
Podophyllotoxin

Substances

picropodophyllin
Podophyllotoxin