Predictive value of serum d-serine level for hearing impairment in uremic patients

Jiaqing Li; Dunlu Yuan; Qing Yang; Jingjing Huang; Zhu Zhou; Ruomei Li; Qing Li

doi:10.1080/0886022X.2023.2194448

Predictive value of serum d-serine level for hearing impairment in uremic patients

Ren Fail. 2023 Dec;45(1):2194448. doi: 10.1080/0886022X.2023.2194448.

Authors

Jiaqing Li¹, Dunlu Yuan¹, Qing Yang¹, Jingjing Huang², Zhu Zhou¹, Ruomei Li³, Qing Li¹

Affiliations

¹ Department of Nephrology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
² Department of Medical Record, The Third People's Hospital of Kunming, Kunming, China.
³ Department of Otolaryngology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

Abstract

Objective: To investigate the predictive value of serum d-serine level for hearing impairment (HI) in uremic patients.

Methods: In this study, 30 uremic patients with HI and 30 with normal hearing were selected. The basic conditions, biochemical indicators, and serum serine levels of the two groups were compared to analyze the influencing factors of HI.

Results: The age and d-serine levels were higher in the HI group, while the l-serine level was lower than uremia in the normal hearing group. Logistic regression analysis showed that d-serine level ≥10 μM and older age increased the risk of HI. The area of the receiver operating characteristic (ROC) curve drawn by the prediction probability of HI was 0.838, indicating that age, d-serine, and l-serine had predictive diagnostic values for HI (p < .001). Among these, the ROC curve area of d-serine in predicting HI in uremic patients was 0.822 (p < .001).

Conclusions: Increased d-serine and age are two risk factors for HI, while l-serine is a protective factor. d-Serine level has a predictive value for HI in uremic patients. Uremic patients are recommended hearing assessment, estimation of d-serine levels, and early intervention.

Keywords: d-Serine; hearing impairment; predictive value; uremic.

MeSH terms

Hearing Loss* / diagnosis
Hearing Loss* / etiology
Humans
ROC Curve
Retrospective Studies
Risk Factors
Uremia* / complications
Uremia* / diagnosis

Grants and funding

This study was supported by grants from the Project of College Education Cooperation Project of Yunnan Province [Grant Number SYSX202034], the Subproject of Fund of CKD Clinical Research Center in Yunnan Province [Grant Number 202102AA100060], the Project of Yunnan Health Training Project of High Level Talents [Grant Number H-2018052], and Hundred of Young and Middle-Aged Academic and Technical Talent in Kunming Medical University [Grant Number 60118260103].