Dioxygen Binding Is Controlled by the Protein Environment in Non-heme FeII and 2-Oxoglutarate Oxygenases: A Study on Histone Demethylase PHF8 and an Ethylene-Forming Enzyme

Shobhit S Chaturvedi; Midhun George Thomas; Simahudeen Bathir Jaber Sathik Rifayee; Walter White; Jon Wildey; Cait Warner; Christopher J Schofield; Jian Hu; Robert P Hausinger; Tatayana G Karabencheva-Christova; Christo Z Christov

doi:10.1002/chem.202300854

Dioxygen Binding Is Controlled by the Protein Environment in Non-heme Fe^II and 2-Oxoglutarate Oxygenases: A Study on Histone Demethylase PHF8 and an Ethylene-Forming Enzyme

Chemistry. 2023 Apr 25;29(24):e202300854. doi: 10.1002/chem.202300854. Epub 2023 Apr 3.

Affiliations

¹ Department of Chemistry, Michigan Technological University, Houghton, MI, 49931, USA.
² Department of Chemical Engineering, Michigan Technological University, Houghton, MI, 49931, USA.
³ Department of Biology, Michigan Technological University, Houghton, MI, 49931, USA.
⁴ The Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
⁵ Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA.
⁶ Department of Chemistry, Michigan State University, East Lansing, MI, 48824, USA.
⁷ Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA.

PMID: 37009811
DOI: 10.1002/chem.202300854

Abstract

Invited for the cover of this issue are Christo Z. Christov and co-workers at Michigan Technological University, University of Oxford, and Michigan State University. The image depicts the oxygen diffusion channel in class 7 histone demethylase (PHF8) and ethylene-forming enzyme (EFE) and changes in the enzymes' conformations upon binding. Read the full text of the article at 10.1002/chem.202300138.

MeSH terms

Ferrous Compounds / metabolism
Histone Demethylases* / metabolism
Humans
Ketoglutaric Acids* / metabolism
Oxygen
Oxygenases
Transcription Factors

Substances

Histone Demethylases
ethylene forming enzyme
Ketoglutaric Acids
Oxygenases
Oxygen
Ferrous Compounds
PHF8 protein, human
Transcription Factors