Influencing factors and adverse outcomes of virologic rebound states in anti-retroviral-treated individuals with HIV infection

Defu Yuan; Mingma Li; Ying Zhou; Lingen Shi; Jing Lu; Gengfeng Fu; Bei Wang

doi:10.1016/j.jve.2023.100320

Influencing factors and adverse outcomes of virologic rebound states in anti-retroviral-treated individuals with HIV infection

J Virus Erad. 2023 Mar 4;9(1):100320. doi: 10.1016/j.jve.2023.100320. eCollection 2023 Mar.

Authors

Defu Yuan¹, Mingma Li¹, Ying Zhou², Lingen Shi², Jing Lu², Gengfeng Fu², Bei Wang¹

Affiliations

¹ Department of Epidemiology and Health Statistics, Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China.
² Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.

Abstract

Antiretroviral therapy (ART) aims to inhibit HIV replication, decrease CD4 T cell loss, and immune function recovery in order to reduce the morbidity and mortality associated with the infection. Treatment should also, improve quality of life and control HIV spread. However, incomplete viral suppression still occurs during ART. Viral suppression and virological failure (VF) thresholds vary between studies in terms of virological rebound (VR) states using different detection thresholds. Further understanding of influencing factors and adverse outcomes in various VR states should provide important guidance for HIV treatment.

Keywords: Antiretroviral therapy; Blips; HIV/AIDS; Low-level viremia; Viral load; Virological failure; Virological rebound.

Publication types

Review